Kamil Ďuriš Research Group: Subarachnoid Hemorrhage

The research group is focused on the pathophysiology of subarachnoid hemorrhage (SAH) in both experimental and clinical conditions. The research is conducted in cooperation with the Clinic of Neurosurgery, University Hospital Brno and the Department of Chemistry and Biochemistry, Mendel University in Brno. The focus of research activities is aimed to study the development of SAH associated early inflammatory response both in brain and periphery. The research framework is not only focused to answer clinically important questions (dynamics of the inflammatory response and its association with severity of bleeding), but the scope of  interest is also concerned with more general concepts (evolution of the inflammatory response, regulation/deregulation of inflammatory response). An important part of research is a testing of treatment options. We are particularly interested in immunomodulation using vagus nerve stimulation. The possibilities and the effects of vagus nerve stimulation is studied in the model of sepsis as well as in the SAH model. Both the direct and indirect vagus nerve stimulation methods are tested.